Understanding the role and mechanism of interaction of small heat-shock proteins in age-related disease [ 2008 - 2010 ]

Also known as: Small heat-shock proteins in age-related disease

Research Grant

[Cite as]

Researchers: Dr John Aquilina (Principal investigator) ,  Prof Carol Robinson

Brief description Protein precipitation is associated with a diversity of age-related diseases such as cataract and Alzheimer's. Within cells, a group of chaperones called the small heat-shock proteins (sHSPs) function by binding to destabilized proteins, however, common in vivo modifications can disrupt their cellular role leading to co-aggregation in a number of age-related diseases. This study will use state of the art mass spectrometry to examine the mechanism by which sHSPs interact with client proteins.

Funding Amount $AUD 270,827.27

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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