[Cite as http://purl.org/au-research/grants/nhmrc/514615]
Dr John Aquilina
Prof Carol Robinson
Brief description Protein precipitation is associated with a diversity of age-related diseases such as cataract and Alzheimer's. Within cells, a group of chaperones called the small heat-shock proteins (sHSPs) function by binding to destabilized proteins, however, common in vivo modifications can disrupt their cellular role leading to co-aggregation in a number of age-related diseases. This study will use state of the art mass spectrometry to examine the mechanism by which sHSPs interact with client proteins.
Funding Amount $AUD 270,827.27
Funding Scheme NHMRC Project Grants
Standard Project Grant