Understanding the regulation of the location of chromosomes within the nucleus [ 2012 - ]

Research Grant

Researchers: Dr Carolyn de Graaf (Principal investigator)

Brief description The nucleus of each human cell, despite being under 10µM in diameter, contains 46 chromosomes, each consisting of several centimeters of DNA. The organisation of chromosomes within the nucleus helps regulate which genes are switched on and off. Genes attached to the nuclear lamina, which lines the nuclear membrane, tend to be switched off. Mutations in the nuclear lamina cause several diseases, including progeria, resulting premature aging. I am interested in understanding why only certain regions of the genome attach to the nuclear lamina.

Funding Amount $333,612.00

Funding Scheme Early Career Fellowships

Notes CJ Martin Biomedical ECF