Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/303705]Researchers: Prof Sally Dunwoodie (Principal investigator) , Dr Duncan Sparrow
Brief description During pregnancy the mammalian fetus depends entirely on its mother for nutrition and oxygen, and to remove waste products. These are exchanged in the placenta, where the blood supplies of the mother and fetus come into close proximity. The placenta is connected to the mother via blood vessels in the uteruine wall, and to the fetus via the umbilical cord. This organ is also involved in making hormones necessary for mammary gland development, suppression of the local immune system to prevent fetal rejection, and production of progesterone required to maintain the pregnancy. Thus failure of correct placenta formation can be associated with a range of complications of human pregnancy, such as missed abortion, miscarriage, intrauterine growth restriction, and pre-eclampsia. The exact cause of these complications is unknown, but by studying mouse models with placental defects we hope to address these issues. Many of the common diseases in society, such as heart attack, stroke and pre-eclampsia, are either directly or indirectly the result of an organ being deprived of oxygen (termed hypoxia). Mammals respond to hypoxia in several different ways to deliver more oxygen to the affected area, such as increasing numbers of oxygen-carrying red blood cells, enlarging existing blood vessels, and making new vessels. Many of the genes involved in this process are known, and one of these is called Cited2. Paradoxically, during gestation hypoxia is crucial for the normal formation of many fetal organs and their blood supply, including the placenta. We have created a mutant mouse by specifically deleting the Cited2 gene. Mutant mouse embryos die during gestation and do not form a fully functional placenta. We will examine these defective placentas in order to understand how this organ needs Cited2 to form. Since the Cited2 gene is turned on by hypoxia, this will also allow us to see if the placental defects are caused by a failure of the normal response to hypoxia.
Funding Amount $AUD 352,500.00
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- nhmrc : 303705
- PURL : https://purl.org/au-research/grants/nhmrc/303705