Understanding the pharmacoregulation of the extracellular calcium sensing receptor. [ 2009 - 2011 ]

Research Grant

Researchers: Prof Arthur Christopoulos (Principal investigator) ,  Arthur David Conigrave ,  Prof Arthur Conigrave ,  Professor Arthur Conigrave

Brief description Calcium sensing receptors (CaSR) are important regulators of hormone release and modulators of kidney transport, digestion-absorption-satiety and bone mass. In each case, CaSRs adopt a characteristically distinct activating mechanism that we will unravel in detail sufficient for the development of novel chemotherapies e.g., for osteoporosis and obesity. We also anticipate early application of CaSR-based therapies to clinically significant genetic disorders e.g., neonatal hyperparathyroidism.

Funding Amount $AUD 744,943.38

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant