Understanding the pathogenesis of mitochondrial disease using iPS cells [ 2012 - 2014 ]

Also known as: Understanding the mechanisms of mitochondrial disease using iPS cells

Research Grant

[Cite as]

Researchers: Prof David Thorburn (Principal investigator) ,  Dr Ann Frazier Prof Justin St. John A/Pr David Nisbet Dr Stefan White

Brief description Induced pluripotent stem (iPS) cells are stem cells derived from adult skin cells that can be converted into cell types such as neurons. iPS cells offer great promise in understanding and treating inherited disorders. However, there are concerns that the “epigenetic memory” of iPS cells has not been completely erased, which may limit the utility of iPS cells. We will evaluate and validate the use of iPS technology in mouse and human models of inherited disorders affecting energy generation.

Funding Amount $AUD 640,372.40

Funding Scheme Project Grants

Notes Standard Project Grant

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