Understanding the myometrial transition at term and preterm labour to guide tocolysis [ 2017 - ]

Research Grant

Researchers: Prof Roger Smith (Principal investigator) ,  Dr Sonika Tyagi ,  Prof Istvan Toth ,  Prof Jonathan Morris ,  Prof Tamas Zakar

Brief description This grant seeks to understand how the muscle cells of the uterus transform at the time of labour. We propose that this transformation is organised by enzymes that modify the histones around key genes. We will test if a similar pathway operates in cases of preterm labour. The results will guide the development of new ways of treating premature labour that will use targeted nanoparticles to deliver siRNA directly to the muscle cells of the uterus.

Funding Amount $808,447.00

Funding Scheme Project Grants

Notes Standard Project Grant