Understanding multidrug resistance in cancer: identification of the substrate and inhibitor binding sites in P-glycoprotein [ 2013 - 2016 ]

Research Grant

Researchers: Dr Megan O'Mara (Principal investigator) ,  A/Pr Richard Callaghan ,  Prof Alan Mark

Brief description Cancers expressing the multidrug transporter P-glycoprotein (P-gp) are resistant to chemotherapy. The clinical impact of P-gp is so large that the National Cancer Institute (USA) “profiles” all anticancer drugs for transport by P-gp, primarily because the mechanism of drug binding and transport by P-gp is unknown. The aim of this proposal is to understand the molecular details of how drugs bind to and interact with P-gp, a major step in our understanding of P-gp mediated chemotherapy resistance.

Funding Amount $AUD 284,343.34

Funding Scheme Project Grants

Notes Standard Project Grant