UNDERSTANDING THE MOLECULAR MECHANISMS CONTROLLING NUCLEOLAR SURVEILLANCE IN DISEASE [ 2016 - ]

Research Grant

Researchers: Prof Richard Pearson (Principal investigator) ,  Dr George Thomas

Brief description Alterations in the ability of cells to make ribosomes, the cellular factories that make protein, contribute to a range of diseases including cancer and a class of inherited disorders called ribosomopathies that are rare but largely untreatable. These changes cause disease by controlling the “nucleolar surveillance pathway” that causes cells to either stop dividing or die. Here we propose to identify new genes that regulate this pathway to identify new targets for treating these diseases.

Funding Amount $855,972.00

Funding Scheme Project Grants

Notes Standard Project Grant