Understanding the mechanisms of atrial fibrillation: High density intra-operative mapping [ 2006 - 2008 ]

Research Grant

Researchers: Dr Haris Haqqani (Principal investigator)

Brief description We hypothesize that: During atrial fibrillation, regions acting as short cycle length drivers will demonstrate characteristic sinus rhythm electrophysiology including conduction slowing and abbreviated refractoriness. We aim to correlate the nature of electrical activity in atrial fibrillation with that in sinus rhythm. We will focus on particular anatomic locations that have been shown to be regions of anisotropy and sites where short cycle length rotors have been observed. The anatomic location and electrophysiologic (EP) characteristics of these regions will vary according to the underlying atrial substrate. We aim to characterise the differences in atrial electrophysiology in AF and sinus rhythm between different pathophysiologic substrates. With high density mapping targeted to critical anatomic sites it will be possible to determine the EP mechanism of short cycle length rotors. We aim to characterise the EP mechanism of these short cycle length regions by analysis of recordings from high density mapping plaques.

Funding Amount $AUD 94,025.00

Funding Scheme NHMRC Postgraduate Scholarships

Notes Medical Postgraduate Scholarship