Understanding the major class of cell surface drug targets [ 2014 - ]

Research Grant

Researchers: Prof Patrick Sexton (Principal investigator) ,  Prof Arthur Christopoulos ,  Prof Nigel Bunnett ,  Prof Roger Summers

Brief description G Protein-Coupled Receptors (GPCRs) form the largest family of receptors and drug targets in living organisms. Currently, the major reason that new drugs fail to reach the clinic is lack of appropriate drug effect (approx. 30%). Thus, we need a better understanding of how GPCRs work and how this relates to disease. Our Program addresses this knowledge gap, using GPCR models that are relevant to treatment of metabolic, inflammatory, cardiovascular and central nervous system disease.

Funding Amount $7,595,840.00

Funding Scheme Programs

Notes Program Grant