Understanding how inflammatory bowel disease causes hypersensitivity of colonic sensory nerve endings and increased abdominal pain [ 2014 - 2016 ]

Also known as: Mechanisms underlying increased pain sensations during colonic inflammatory bowel disease

Research Grant

[Cite as]

Researchers: Prof Nicholas Spencer (Principal investigator) ,  Dr Vladimir Zagorodnyuk Prof Simon Brookes

Brief description Patients with inflammatory bowel disease (IBD) commonly experience increased abdominal pain. This project utilises two novel techniques developed by the Chief investigator, that allow us to understand how inflammation of the large intestine leads to increased pain sensations. This project will use these new techniques to identify, for the first time, the sensory nerve endings that detect painful stimuli from within the large intestine; and how these nerve endings become hyperexcitable during inflammation to cause increased abdominal pain.

Funding Amount $AUD 589,466.11

Funding Scheme Project Grants

Notes Standard Project Grant

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