grant

Understanding changes in the mammalian prenylome induced by statins and prenyltransferase inhibitors [ 2009 - 2011 ]

Also known as: Understanding drug induced changes in protein prenylation

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/569652]

Researchers: Prof Kirill Alexandrov (Principal investigator) ,  Daniel Abankwa

Brief description Prenylation, the covalent attachment of isoprenoid lipids to proteins, is widespread in mammalian cells. Essential for a protein's normal function, it contributes to the progression of cancer and inflammation. We have developed a novel technology to identify all prenylated proteins in the cell. Aided by this method, we will analyse the effect of statins and anti-cancer drugs on protein prenylation. This will provide guidance in identifying a more effective clinical use for them.

Funding Amount $AUD 566,308.79

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Identifiers
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ACN 633 798 857