Understanding allosteric modulation and biased signalling at Family B GPCRs [ 2015 - ]

Research Grant

Researchers: Dr Denise Wootten (Principal investigator)

Brief description Family B GPCRs are therapeutic targets for drugs treating osteoporosis, hypercalcaemia, Paget’s disease, type II diabetes and are being actively pursued for other diseases that represent major global health burdens. Despite huge financial input, there are no orally available drugs that act on these receptors. This speaks to a lack of mechanistic understanding of how they work. My research focuses on addressing this question and how to exploit these receptors to design and identify better drugs.

Funding Amount $411,768.00

Funding Scheme Career Development Fellowships

Notes RD Wright Biomedical CDF