Uncovering new epigenetic-based regulatory mechanisms of gene expression: novel links between histone variants, RNA function and disease [ 2018 - ]

Research Grant

Researchers: Prof David Tremethick (Principal investigator) ,  Dr Tatiana Soboleva

Brief description It is estimated that greater than 90% of human genes undergo alternative RNA splicing, which can explain how protein diversity is achieved with a limited number of genes. However, how alternative splicing patterns are established remains poorly understood but is an important question given that 15-50% of human disease mutations are associated with changes to the splicing patterns of RNA. We have uncovered a new splicing mechanism, which involves changing the way DNA is packaged in a cell.

Funding Amount $1,053,671.00

Funding Scheme Project Grants

Notes Standard Project Grant