UDP glucuronosyltransferases as regulators of signaling pathways modulated by chemical ligands. [ 2007 - 2009 ]

Research Grant

Researchers: E/Pr Peter Mackenzie (Principal investigator) ,  Prof John Miners

Brief description Cells respond to their surroundings by transferring information received at the cell surface to the nucleus leading to changes in gene expression. There are many signaling pathways which transfer this informatrion to the nucleus. Some of these pathways are controlled by small molecules, usually fat-soluble chemicals. As a family of enzymes, the UDP glucuronosyltransferases (UGT) have evolved to eliminate fat-soluble chemicals, we propose that UGTs play a pivotal role in regulating the concentrations of fat-soluble chemicals involved in signaling, and thus are important in controlling gene expression. We intend to provide evidence for this novel role of UGTs in this project. This information will be used to alter the response of the cell to its environment. For example, to help protect the cell against environmental toxins, or to make a cancer cell more susceptible to a chemotherapeutic agent.

Funding Amount $AUD 500,460.05

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant