Tyrosine kinase receptor c-ros-oncogene 1 mediates Twist-1 haploinsufficiency induced craniosynostosis in children: A novel therapeutic target [ 2017 - ]

Research Grant

Researchers: Prof Stan Gronthos (Principal investigator) ,  Prof Andrew Zannettino ,  Prof Peter Anderson

Brief description Children with Saethre-Chotzen syndrome exhibit premature fussed coronal sutures, and other skull/ skeletal malformations. Surgical intervention is the only treatment option to ensure optimal cognitive and skeletal development. Our studies have identified a candidate molecular pathway that regulates bone formation by cranial bone cells from these patients. Targeting these key molecular signalling components with chemical inhibitors will help prevent the premature fusion of cranial sutures.

Funding Amount $562,863.00

Funding Scheme Project Grants

Notes Standard Project Grant