The tumour suppressor Lgl in the regulation of cell signaling, proliferation and apoptosis [ 2008 - 2010 ]

Research Grant

Researchers: A/Pr Helena Richardson (Principal investigator) ,  Dr Nicola Grzeschik ,  Prof Patrick Humbert

Brief description Cancer is a disease that affects 1-3 people at some point in their lifetime. Therefore, understanding what causes cancer is of major importance to medical science. This proposal focuses on a group of tumour suppressors, Scrib-Dlg-Lgl, which act in a common pathway to regulate cell polarity (cell shape) and proliferation. We have shown that Lgl also regulates cell death. This proposal focuses on understanding the mechanism by which Lgl regulates the cell proliferation and death machinery.

Funding Amount $AUD 534,871.14

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant