Trophoblast cell-cell fusion in preeclampsia [ 2017 - 2019 ]

Research Grant

Researchers: Dr David Simmons (Principal investigator) ,  Dr Dominic Ng ,  Dr Marloes Dekker ,  Prof Leonie Callaway

Brief description Cell-cell fusion is critical for the development and transport capacity of the placenta during pregnancy. Impairments in this process occur in pregnancy complications such as preeclampsia (PE). We have identified a novel pathway (LY6E) regulating placental cell-cell fusion which is also dysregulated in human pregnancies complicated by PE. In the current proposal we will investigate the mechanisms by which LY6E mediates cell-cell fusion and examine its role in the development of PE.

Funding Amount $AUD 498,753.69

Funding Scheme Project Grants

Notes Standard Project Grant