TRF2 protein and t-loop replication in Alternative Lengthening of Telomeres [ 2008 - 2010 ]

Research Grant

Researchers: Prof Roger Reddel (Principal investigator) ,  Dr Lorel Colgin

Brief description Telomere loss acts as a clock telling cells when to stop proliferating. Cancer cells ignore this clock and grow indefinitely by preventing the normal loss of telomeres. Little is known about one of the methods cancers use to preserve telomeres, called ALT, which is employed by some brain tumours and other cancers. We will determine if the TRF2 protein is involved in controlling ALT. This will lay the basis for future anti-cancer treatments targeted at ALT.

Funding Amount $AUD 398,156.94

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant