Full description
In-vitro antibacterial and antibiofilm activity of savirin or ticagrelor, alone and in combination with cefazolin, vancomycin, and rifampicin, against Staphylococcus aureus was tested. Effect of savirin or ticagrelor on the expression of key biofilm-related genes in S. aureus was also studied. Finally effect of savirin or ticagrelor, alone and in combination with cefazolin, to treat biofilm-related S. aureus prosthetic joint infection was studied in a mouse model. These experiments were performed to collect data to study the in-vitro antibacterial and antibiofilm activity of savirin or ticagrelor, alone and in combination with antibiotics, to study the effect of savirin or ticagrelor in the expression of key biofilm-related genes in S. aureus, and to study the effectiveness of savirin or ticagrelor, alone and in combination with cefazolin, to treat biofilm-related S. aureus prosthetic joint infection in an animal model. The antibacterial and antibiofilm activity of human synovial fluid against Staphylococcus aureus was also studied. The data generated were stored and analysed using graphpad. One way ANOVA followed by Tukey multiple comparison test was used.
Software/equipment used to create/collect the data: GraphPad version 8.2.0
Software/equipment used to manipulate/analyse the data: GraphPad version 8.2.0
Notes
This dataset consists of 5 GraphPad PRISM projects (.pxfx) and a zipped file containing XML versions of the data files and information.Created: 2022-12-01
User Contributed Tags
Login to tag this record with meaningful keywords to make it easier to discover
- Local : researchdata.jcu.edu.au//published/c991100067a711edacc8abe58a36f1d0
