Which transgenic pig will be used for islet transplantation in humans? [ 2007 - 2013 ]

Research Grant

Researchers: Prof Anthony D'Apice (Principal investigator) ,  A/Pr Mark Nottle ,  Prof Andrew Lew ,  Prof Peter Cowan ,  Prof Philip O'Connell
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Brief description We propose that xenotransplantation of pig islets will cure Type 1 diabetes. This program will generate genetically modified pigs to overcome the molecular differences between pigs and humans by removing a pig gene and inserting several human genes. In addition, we will add immunosuppressive genes and so minimise the need for drug treatment of the diabetic recipient. We will test our hypothesis by transplanting islets from these genetically modified pigs into baboons. We suggest that this will provide an inexhaustible supply of islets for transplantation.

Funding Amount $AUD 3,031,083.60

Funding Scheme NHMRC Strategic Awards

Notes Diabetes Collaborative Research Grants