Transcriptional targets of the MEN1 tumour suppressor in endocrine cancer [ 2005 - 2007 ]

Research Grant

Researchers: Dr Graham Kay (Principal investigator) ,  Prof Nicholas Hayward

Brief description We have developed mouse models of a human cancer syndrome called multiple endocrine neoplasia type 1 (MEN 1) by inactivating the tumour suppressor gene responsible. These mice devlop tumours of a wide variety of different tissues, including the pancreas, pituitary, parathyroids and gonads. The data obtained from this project will be the first major step towards determining the mechanism by which the Men1 gene functions as a tumour suppressor and should shed light on its role in normal cell cycle regulation. Findings from murine models of endocrine cancer will lead to a better understanding of MEN 1 in particular, and also of carcinogenesis in general. Defining the cellular pathways normally disrupted by loss of the MEN 1 gene will be useful in designing therapeutic approaches to control endocrine tumours and some other types of cancer.

Funding Amount $AUD 454,500.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant