grant

Transcriptional Regulation of Terminal T cell Differentiation by Blimp-1 [ 2008 - 2010 ]

Also known as: Regulation of T cell memory by the transcription factor Blimp-1

Funded by National Health and Medical Research Council
Managed by The Walter and Eliza Hall Institute of Medical Research
Managed by Walter and Eliza Hall Institute
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/516755]

Researchers: Prof Axel Kallies (Principal investigator) ,  Prof Gabrielle Belz

Brief description Memory cells stand at the end of immune reactions and determine the success or failure of vaccination. T cells in are considered essential in tumour surveillance, clearance of infections and in providing help for antibody decretion. Blimp-1 is a major factor controling the differentiation of effector T cells. We aim to study its role in the generation of memory T cells which will help to develop better stratagies for immunization and for the treatment of immunodedeficiency and autoimmunity.

Funding Amount $AUD 411,404.21

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Autoimmunity | Biomedical and Clinical Sciences | Clinical Chemistry (Incl. Diagnostics) | Clinical Sciences | Immunity | Infections | Leukaemia | T cells | Vaccination | autimmunity | immune response | memory | transcription factor |
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ACN 633 798 857