Transcriptional and Epigenetic Regulation of Epithelial Mesenchymal Plasticity in Breast Cancer Dissemination [ 2012 - 2015 ]

Research Grant

Researchers: Prof Erik Thompson (Principal investigator) ,  A/Pr Alexander Dobrovic ,  Dr Bryce Van Denderen ,  Dr Nicholas Wong

Brief description Fuelling the spread of breast cancer are small clusters or individual cancer cells that escape into the blood (CTC) and bone marrow (DTC). Comprehensive analysis of these is prohibited by difficulty in purifying them, and their small numbers. Using two novel, validated mouse models for these cells, we have devised an approach that will identify new diagnostic and therapeutic targets in these compartments. These will ultimately provide avenues to improve breast cancer survival.

Funding Amount $AUD 670,964.38

Funding Scheme Project Grants

Notes Standard Project Grant