Transcriptional complexes in haematopoiesis and T-cell Leukemia [ 2008 - 2011 ]

Research Grant

Researchers: Prof Jacqueline Matthews (Principal investigator) ,  E/Pr Jules Guss ,  Prof Jill Trewhella

Brief description Childhood T-cell leukemias have a poor prognosis for recovery. We are determining, with atomic level precision, how the proteins LMO2 (also linked to prostate and other cancers) and Tal1, and their binding partners contribute to both normal blood cell development and T-cell leukemia. With this information we are developing reagents that can be used to disrupt disease-causing complexes, and which will lead towards the development of new, specific, therapeutics for leukemias and other cancers.

Funding Amount $AUD 557,939.08

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant