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The transcription factors c-Rel and RelA serve distinct roles in the devlopment and function of CD4 Regulatory T cells [ 2009 - 2012 ]

Also known as: The role of NF-kB transcription factors in Regulatory T cells

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/543141]

Researchers: Prof Steve Gerondakis (Principal investigator) ,  Prof Frances Shannon

Brief description An unfortunate consequence of immune function is that occasionally rogue immune cells are produced that attack the host and lead to the development of so-called autoimmune diseases such as arthritis. Normally a white blood cell called a regulatory T cell suppresses these self reactive immune cells. We have identified factors that govern genetic programs in regulatory T cells. Understanding how these factors work should permit the development of new strategies to combat autoimmune diseases.

Funding Amount $AUD 492,991.29

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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