grant

A transcription factor network constraining the development of B cell leukaemia [ 2010 - 2012 ]

Also known as: The role role of gene regulators in B cell leukemia

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/637359]

Researchers: Prof Axel Kallies (Principal investigator) ,  Dr Sebastian Carotta Prof Lynn Corcoran

Brief description B cell leukemias are relatively common, often aggressive hematopoietic malignancies and their cause is unknown in many cases. We have found that deficiencies in several transcription factors that normally control B cell differentiation cause B cell leukemias at a high frequency. We wish to identify the key pathways that are regulated by these factors and, in normal cells, prevent leukemic transformation. This will help to identify potential targets for therapeutic intervention.

Funding Amount $AUD 617,531.44

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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