Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/143094]Researchers: Prof Daniel Markovich (Principal investigator)
Brief description Many diseases such as diabetes, cystic fibrosis, Alzheimer's and Parkinson's, results from a defect in the intracellular trafficking of specific membrane proteins. One important family of membrane proteins are the renal sulphate transporters, NaSi-1 and sat-1. They are two important proteins that control body sulphate homeostasis. Sulphate in the body is essential for cell matrix formation and cartilage-bone development and growth. Trafficking defects in these proteins can lead to changes in serum sulphate levels, which results in softening of the bones, insufficient cartilage development, and changes in many metabolic processes. Using techniques of molecular and cellular biology, we aim to identify the precise the mechanisms that control the trafficking of these proteins in cells. This will enable us to determine how these proteins functions in both the normal and diseased states, which is currently unknown.
Funding Amount $AUD 211,527.54
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- nhmrc : 143094
- PURL : https://purl.org/au-research/grants/nhmrc/143094
