Trafficking and expression of PfEMP1 on the surface of P.falciparum-infected erythrocytes [ 2008 - 2010 ]

Research Grant

Researchers: Prof Alan Cowman (Principal investigator) ,  Dr Melanie Rug ,  Dr Svenja Gunther ,  Prof James Beeson

Brief description Malaria causes over 2 million deaths each year. The parasite infects human red blood cells and expresses a virulence protein on the erythrocyte surface allowing it to adhere to the microcapillaries preventing clearance through the spleen. We aim to understand how the parasite is able to express this virulence protein on the parasite-infected red blood cell surface. Identification of the proteins involved will provide potential drug targets to develop novel antimalarial compounds and strategies.

Funding Amount $AUD 558,189.08

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant