Full description
This dataset contains information collected from an international multi-site longitudinal study. Julie Stout was the only Australian investigator in a project led by Professor Sarah Tabrizi at University College London which was funded by the CHDI (Cure Huntington's Disease Initiative) Foundation. The aim of the project was to evaluate potential biological markers for clinical trials in Huntington’s Disease in the early and premanifest periods. The data comprises clinical and demographic patient information; cognitive, neuropsychiatric, oculomotor and quantitative motor data; brain imaging (Magnetic Resonance Imaging); and blood, tissue and genetic markers for 360 participants. The participants were recruited from four international sites - London, Paris, Leiden, and Vancouver. The data was collected annually from the study participants between 2008 and 2011.
Notes
The data consists of records for each of the 360 participants collected annually for four years. It includes clinical and demographic information; cognitive test results (10 tests x 150 trials x 4 responses; neuropsychiatric data; oculomotor data; quantitative motor data; brain imaging (MRIs); blood, tissue and genetic samples.
Significance statement
The availability of sensitive and reliable biomarkers will make it possible to do efficient clinical trials in Huntington’s Disease that will run for the shortest duration possible and with the smallest sample size.
Data time period: 2008 to 2011
Spatial Coverage And Location
iso31662: CA-BC
iso31662: FR-75
iso31662: GB-LND
iso31662: NL-ZH
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- Handle : 1959.1/489132
