TOLERANCE OR REJECTION – THE ROLE OF INNATE IMMUNITY IN DETERMINNG THE FATE OF A KIDNEY ALLOGRAFT [ 2012 - 2015 ]

Research Grant

Researchers: Prof Steven Chadban (Principal investigator) ,  A/Pr Huiling Wu ,  Prof Stephen Alexander

Brief description Transplantation is the optimal management for people with organ failure. Tolerance, to retain transplant function without immunosuppression, remains the key goal but is seldom achieved. We propose to block Toll-like receptor signalling to achieve kidney transplant tolerance in mice. If successful, we would translate this into clinical trials in human, seeking to achieve organ transplantation without the risks of cancer, infection and premature death that are currently faced by organ recipients.

Funding Amount $AUD 506,413.54

Funding Scheme Project Grants

Notes Standard Project Grant