Tissue ferritin is a damage-associated molecular pattern (DAMP) in inflammasome-induced inflammation associated with hepatic stellate cell activation and fibrogenesis in chronic liver disease. [ 2018 - ]

Research Grant

Researchers: Prof Grant Ramm (Principal investigator) ,  Prof Darrell Crawford

Brief description We have generated considerable evidence for a role for tissue ferritin as a mediator of inflammation associated with liver fibrosis (scarring) These highly novel and innovative studies will assist in identifying pathways involved in the proinflammatory phenotype of hepatic stellate cells (scar-forming cells in the liver) in chronic liver disease and thus will greatly aid in understanding how liver scarring occurs in chronic liver disease.

Funding Amount $783,612.00

Funding Scheme Project Grants

Notes Standard Project Grant