Tissue ferritin acts as a proinflammatory mediator of hepatic fibrosis in chronic liver disease via multiple receptors in hepatic stellate cells responsible for both binding and signalling.

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1064533]

Researchers: Prof Grant Ramm (Principal investigator) , Prof Darrell Crawford

Brief description Our research has identified a role for tissue-derived ferritin as a proinflammatory cytokine in hepatic stellate cell biology, the cells responsible for liver scarring (fibrosis) in Haemochromatosis. This proposal will identify the receptor responsible for eliciting ferritin's proinflammatory action and assess its role in fibrosis. This study will have implications in chronic liver diseases of varying aetiologies where elevated serum ferrritin is associated with inflammation.

Funding Amount $AUD 777,887.28

Funding Scheme Project Grants

Notes Standard Project Grant

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nhmrc : 1064533
PURL : https://purl.org/au-research/grants/nhmrc/1064533

Tissue ferritin acts as a proinflammatory mediator of hepatic fibrosis in chronic liver disease via multiple receptors in hepatic stellate cells responsible for both binding and signalling. [ 2014 - 2017 ]

Research Grant

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