The therapeutic value of targeting Wnt signalling for the treatment of Osteoarthritis [ 2011 - 2013 ]

Also known as: Function and Regulation of Wnt Signalling in Osteoarthritis

Research Grant

[Cite as]

Researchers: Dr Nicole Walsh (Principal investigator) ,  A/Pr Evange Romas A/Pr Natalie Sims

Brief description Osteoarthritis (OA) affects 1.62 million Australians and imposes a significant burden on healthcare. It is characterised by damage to joint cartilage, and increased bone formation with formation of bone spurs. Our studies will determine the importance of the Wnt signalling pathway in mediating OA joint degeneration and identify mechanisms that regulate the activation of this pathway in OA. This will inform the development of novel therapeutic strategies which could halt joint damage in OA.

Funding Amount $AUD 561,535.37

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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