Therapeutic targeting of MYCN oncoprotein stability in neuroblastoma [ 2017 - 2019 ]

Research Grant

Researchers: Prof Glenn Marshall (Principal investigator) ,  Dr Belamy Cheung ,  Dr Jessica Holien

Brief description A high level of MYCN protein is a major indicator of aggressive neuroblastoma (NB) but unfortunately there have been many barriers to the design of targeted therapies. We have identified a protein called PA2G4 which is a cofactor for MYCN in promoting cancer cell growth. We have developed a compound which inhibits PA2G4 and MYCN protein levels and reduces tumour growth. We will examine how PA2G4 cause aggressive tumour characteristics and test new methods to block PA2G4.

Funding Amount $AUD 603,858.59

Funding Scheme Project Grants

Notes Standard Project Grant