Therapeutic targeting of the colorectal cancer epigenome [ 2018 - ]

Research Grant

Researchers: A/Pr Ron Firestein (Principal investigator) ,  A/Pr Joseph Rosenbluh

Brief description Enhancer RNAs (eRNAs) are a new class of noncoding RNA molecules that have been linked to diverse functions that impinge on cancer, but their clinical relevance is unknown. Our work shows that distinct eRNAs are expressed in a subset of cancer and predict which cancer will respond to a cancer therapeutic agent called a BET inhibitor. Our proposal uses sophisticated preclinical models and cutting edge technology to investigate the functional role of enhancers and enhancer templated RNA in cancer.

Funding Amount $537,045.00

Funding Scheme Project Grants

Notes Standard Project Grant