THE IMMUNOLOGICAL LEGACY OF OBESITY ON VIRAL PATHOGENESIS [ 1/1/2021 - 12/31/2023 ]

Research Grant

Brief description Obesity is a key risk factor for severe viral infections. Our preliminary data suggest that in mice this susceptibility is not reduced by weight loss. In this grant we will investigate a) the mechanisms driving the legacy effect of obesity on antiviral immunity b) whether or not we can reverse this legacy effect by treatment with the drug MCC950 and c) the antiviral response of overweight children and adults who have and haven't recently lost weight.

Funding Amount $652,275

Funding Scheme Ideas Grants

Chief Investigator Dr Kirsty Short

Notes Ideas Grants