grant

Targeting small airways to overcome resistance to therapy in asthma [ 2013 - 2015 ]

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1041575]

Researchers: Dr Jane Bourke (Principal investigator) ,  Dr Simon Royce Prof Michael Sanderson A/Pr Kenneth Snibson

Brief description There is a pressing need to overcome resistance to current therapies for severe asthma. Targetting inflammation-induced changes in small airway contraction offers an alternative strategy. We have identified a novel bronchodilator that relaxes maximally contracted mouse small airways when current treatment is ineffective. We will demonstrate its efficacy in animal models mimicking key features of human asthma, and define new ways to improve outcomes in poorly-controlled asthma.

Funding Amount $AUD 531,045.18

Funding Scheme Project Grants

Notes Standard Project Grant

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