Targeting Schistosome Calcium Signalling to Improve and Broaden Praziquantel Efficacy [ 2015 - ]

Research Grant

Researchers: Dr Geoffrey Gobert (Principal investigator) ,  Dr Hong You (Principal investigator) ,  Prof Paul Brindley ,  Prof Robin Gasser

Brief description Schistosomiasis is caused by parasitic worms, treatment relies solely on praziquantel (PZQ). Schistosomes respond and recover from PZQ exposure through modulation of the gene CamKII. We will target this gene to both increase and extend the efficacy of PZQ in both adult parasites and in refractory juvenile parasites. Research will expand into assaying CamKII inhibitors to maximise effectiveness and take this work into animal models of this disease.

Funding Amount $466,514.00

Funding Scheme Project Grants

Notes Standard Project Grant