grant

Targeting Post-translational Modifications in TRPV Pain Channels [ 2009 - 2012 ]

Also known as: Searching for new ways to reduce signalling through pain sensors

Funded by National Health and Medical Research Council
Managed by The University of Melbourne
Managed by University of Melbourne
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/566834]

Researchers: Prof Peter Mcintyre (Principal investigator) ,  Prof Nigel Bunnett

Brief description The same nerve receptor that binds the pungent component of chilli peppers (TRPV1) is an important part of our pain pathway. TRPV1 also responds to painful heat and acids. Chronic pain is an important unmet medical need and it uses the TRPV1 pathway. After activation by chilli, a feedback system in nerves inactivates TRPV1 and stops pain signalling. This feedback changes in chronic pain. This project aims to understand and exploit this feedback mechanism to find new approaches to pain therapy.

Funding Amount $AUD 480,127.04

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Biomedical and Clinical Sciences | Medical Biochemistry - Carbohydrates | Medical Biochemistry and Metabolomics | chronic pain | ligand-gated ion channels | molecular pharmacology | osteoarthritis | painful neuropathy | pancreatitis | protein kinases | receptor trafficking |
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