Targeting polymyxin-resistant Gram-negative superbugs: development of novel antimicrobial lipopeptides [ 2010 - 2012 ]

Research Grant

Researchers: Prof Jian Li (Principal investigator) ,  Dr Tony Velkov ,  Prof Philip Thompson ,  Prof Roger Nation

Brief description Prevalence of resistance to antibiotics among Gram-negative 'superbugs' is a major global medical challenge, which is highlighted by the Bad Bugs, No Drugs campaign of the Infectious Diseases Society of America. There are virtually no new antibiotics in the current drug development pipeline for these dangerous pathogens. In this project, novel lipopeptides will be designed, synthesised and evaluated against these 'superbugs'. Information obtained will be crucial for further drug development.

Funding Amount $AUD 661,069.65

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant