grant

Targeting neuroserpin-plasmin interactions to protect the retina in glaucoma [ 2018 - 2020 ]

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1147404]

Researchers: Prof Stuart Graham (Principal investigator) ,  Prof Mark Baker Dr Vivek Gupta

Brief description Glaucoma causes blindness and despite our best treatment many patients continue to progress. A new approach is needed to protect the cells that die in the retina. We have established that a common protease – plasmin – is involved in the process, and a protein that normally regulates it – neuroserpin – is downregulated in the disease. We aim to modify neuroserpin using an ocular gene therapy approach and show it could be used as a novel therapy in glaucoma.

Funding Amount $AUD 648,965.07

Funding Scheme Project Grants

Notes Standard Project Grant

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