Targeting NDM-producing ‘superbugs’: optimising novel combinations with ‘old’ polymyxins using pharmacological, molecular imaging and systems biology approaches [ 2013 - 2015 ]

Research Grant

Researchers: Prof Jian Li (Principal investigator) ,  A/Pr John Boyce ,  Dr Jing Fu ,  Dr Mark Butler ,  Prof Roger Nation

Brief description Rapid global spread of so-called NDM-producing bacterial ‘superbugs’ is presenting a major medical challenge. Without new antibiotics under development, polymyxin is becoming the only effective antibiotic. Unfortunately we recently revealed that treatment with polymyxin alone can rapidly lead to resistance in NDM-producing ‘superbugs’. This project will employ new tools to optimise rational polymyxin combinations, thereby providing urgently needed information to clinicians for treating these very problematic infections.

Funding Amount $AUD 582,732.73

Funding Scheme Project Grants

Notes Standard Project Grant