Targeting KRAS mutations in cancer using a novel siRNA delivery technology [ 2011 - 2013 ]

Research Grant

Researchers: Prof Benjamin Solomon (Principal investigator) ,  Dr Carleen Cullinane ,  Dr Himanshu Brahmbhatt ,  Dr Jennifer Macdiarmid ,  Prof Grant Mcarthur

Brief description Mutations in a gene called KRAS are found in 20% of human cancers but are impossible to target with existing treatments. RNA interference is a promising new way to target genes previously considered undruggable, but there is no way to deliver the molecules required for RNA interference to tumours. We will evaluate the ability of a new nanotechnology based delivery system (antibody targeted minicells) to deliver RNA interference, thereby selectively targeting of KRAS in tumours while avoiding toxicity to normal tissue.

Funding Amount $AUD 498,899.66

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant