Targeting the JNK-JUN pathway to overcome therapy resistance in melanoma [ 2017 - 2020 ]

Research Grant

Researchers: Dr Petranel Ferrao (Principal investigator) ,  Dr Andreas Behren ,  Dr Gideon Bollag ,  Dr Katherine Woods ,  Dr Robert Jorissen

Brief description Melanoma patients can display remarkable responses to targeted and immunotherapies. However most patients progress rapidly on targeted therapies and only a small proportion respond to immunotherapies. We have found that combination treatment with JNK inhibitors can overcome therapy resistance. We will determine the most efficacious JNK inhibitors available, and the optimal dosing and scheduling of combination treatment for evaluation in patients to improve responses, outcomes and survival.

Funding Amount $AUD 712,029.22

Funding Scheme Project Grants

Notes Standard Project Grant