Targeting insulin hypersecretion to prevent type 1 and type 2 diabetes [ 2017 - 2020 ]

Research Grant

Researchers: Prof Christopher Nolan (Principal investigator) ,  Prof Marc Prentki ,  Prof Stefan Broer

Brief description Diabetes develops when islet beta-cells fail to secrete insulin. While major differences exist in the mechanisms by which type 1 and type 2 diabetes develop, there is overlap in beta-cell susceptibility factors. We will investigate whether an islet 'overwork' response to excess nutrient loads underlies beta-cell susceptibility to failure in both types of diabetes. We will also develop novel pharmacological approaches to reduce islet 'overwork' to prevent and treat type 1 and 2 diabetes.

Funding Amount $AUD 855,272.77

Funding Scheme Project Grants

Notes Standard Project Grant