Targeting hypermutable ‘superbugs’ in chronic respiratory infections by optimised antibiotic combination dosage regimens [ 2016 - ]

Research Grant

Researchers: Dr Cornelia Landersdorfer (Principal investigator) ,  A/Pr Antonio Oliver ,  A/Pr John Boyce ,  Dr Jurgen Bulitta ,  Prof Roger Nation

Brief description Many bacterial ‘superbugs’ can increase their mutation rate, i.e. become hypermutable, and thus rapidly become resistant to multiple antibiotics. Chronic lung infections with hypermutable bacteria cause increased ill-health and death in patients and current treatments do not work well. We will develop improved treatments using combinations of available antibiotics. This project will provide guidance to doctors on how to treat infections more effectively and minimise emergence of resistance.

Funding Amount $697,731.00

Funding Scheme Project Grants

Notes Standard Project Grant