Targeting the histone methyltransferase DOT1L for the therapy of Myc-induced malignancies [ 2013 - 2015 ]

Research Grant

Researchers: A/Pr Tao Liu (Principal investigator) ,  A/Pr Christopher Scarlett ,  Prof Yi Zhang

Brief description Neuroblastoma is the commonest solid tumour in early childhood. Pancreatic cancer is the fourth leading cause of cancer death in adults. In this application, we will define how a protein called histone methyltransferase DOT1L promotes cancer initiation and progression, and whether inhibitors of the histone methyltransferase DOT1L exert efficient anti-cancer effects against neuroblastoma and pancreatic cancer.

Funding Amount $AUD 356,127.88

Funding Scheme Project Grants

Notes Standard Project Grant