Targeting Histone Deacetylases to Overcome Resistance of BRAFV600E Melanoma Cells to Apoptosis [ 2012 - 2014 ]

Research Grant

Researchers: Prof Xu Dong Zhang (Principal investigator) ,  A/Pr Tao Liu ,  Dr Chen Chen Jiang ,  Dr Rick Thorne ,  Prof Peter Hersey

Brief description Results from early clinical studies with a new class of drugs in the treatment of melanoma have been very encouraging, but most tumors initially respond to the drugs regrow after short periods. We have recently shown that this is mainly related to resistance of melanoma cells to cell death induced by the drugs. In this project, we aim to explore a novel approach to overcome this resistance. If successful, the results will lead to new approaches in the treatment of melanoma.

Funding Amount $AUD 353,140.27

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant