[Cite as http://purl.org/au-research/grants/nhmrc/1057762]
Prof Wallace Langdon
Brief description Most leukaemias are incurable so it is important to find new treatments. For this to occur it is essential that the mutated genes that cause leukaemia are identified. We have generated a mouse with a mutation in a gene called c-Cbl that promotes the activation a protein called FLT3 that is involved in the development of many types of leukaemias. By treating mutant mice a drug that specifically suppresses the function of FLT3 we intend to identify the most effective treatments for human leukaemias associated with activated forms of FLT3.
Funding Amount $AUD 673,045.39
Funding Scheme Project Grants
Standard Project Grant